OUTSTANDING OBSERVATION Naı̈ve blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity
نویسندگان
چکیده
In certain disease context, cells of the monocyte/macrophage lineage are known to exhibit T-cell suppressor function. However, whether naı̈ve monocytes are also able to suppress T-cell responses has not been previously investigated. In this study, we have discovered that CD11b+Ly6G mononuclear cells in the blood of naı̈ve mice are potent suppressors of T-cell proliferation in vitro. The suppression of T-cell proliferation requires cell-cell contact and is partially dependent on nitric oxide production. Following the induction of experimental autoimmune encephalomyelitis in mice, the suppressor function of this blood CD11b+Ly6G cell population is impaired. Therefore, blood CD11b+Ly6G cells appear to be intrinsically suppressive and may have a key role in maintaining immune homoeostasis. Loss of this suppressive function may contribute to development of autoimmunity. Immunology and Cell Biology (2011) 89, 7–13; doi:10.1038/icb.2010.110; published online 9 November 2010
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